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#Analysis of recent #scientific #information on #avian #influenza A(#H7N9) virus - 10 February 2017 (@WHO, edited)

  Title : #Analysis of recent #scientific #information on #avian #influenza A(#H7N9) virus - 10 February 2017. Subject : Avian Influenza, ...

26 Feb 2017

CAS’s #ZhongNanshan said the finding of two #H7N9 #flu virus #resistant to #antivirals is matter of #concern (Feb. 26 ‘17)

 

Title: CAS’s Zhong Nanshan said the finding of two H7N9 flu virus resistant to antivirals is matter of concern.

Subject: Avian Influenza, H7N9 subtype, a highly pathogenic variant virus found to be also resistant to neuraminidase inhibitors drugs.

Source: Local Media, full page: (LINK). Article in Chinese, edited.

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Zhong Nanshan: H7N9 virus mutant showed drug resistance, urged people do not buy live birds

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09:13 2017-02-26

"Two H7N9 avian influenza viruses found in Guangdong were resistant to antiviral drugs."

At the 13th International Symposium … held yesterday, Zhong Nanshan, an academician, told reporters that the two strains found recently Poultry showed highly pathogenicity trait for birds, and according to the present situation, the most critical step is to prevent and control from the source to solve. Do not do be involved live poultry trade, but also to persuade the public not to buy live birds.

Death rate of more than 40%? "Not necessarily"

According to data released by the State Inspector General's Bureau of Disease Control and Prevention on February 14, as of January this year, 17 provinces and cities in China have reported H7N9 human cases of avian influenza infection with a total of 192 people infected with the disease, of which 79 People died.

The high incidence of the epidemic this year scattered in the Yangtze River Delta and the Pearl River Delta region. As of the current public report (February 25), Jiangsu Province, the largest number of infections, up to 124 people, of which 35 were killed. Zhejiang, Guangdong is also the hardest hit, in January this year, our province reported a total of 21 cases of H 7N 9 cases, 10 cases of death cases.

It is noteworthy that in January this year, Guangdong Province CDC from two cases of human infection, H7N9 virus have been isolated and sequenced. In the two isolates the hemagglutinin showed a multi-aminoacids residue at the cleavage site, and on  February 19, the test results have been confirmed by the National Center for Disease Control and Prevention of the National Influenza Center.

Zhong Nanshan said that the transition of the virus to a more pathogenic variant for birds does not mean the same is true for humans. So far the virus does not seem to be more infectious, but a firm conclusion could not be made.

But it is worth noting that this year's epidemic has two characteristics: First, the number of patients in January is far more higher than in January last year, and the infection is more widespread that before.

Statistics show that this year H 7N 9 epidemic mortality rate is more than 40%, disease control experts believe that this is due to missed the best treatment time. However, for this figure, Zhong Nanshan said: "Because the current number of the total population affected can not be known for sure, confirmed cases are generally the most severe, this does not mean that the overall case-fatality rate is actually so high."

 

"Most of the virus isolated so far showed no variation"

Zhong Nanshan revealed that this mutation has two characteristics: First, the original H7N9 virus is low pathogenicity strain for birds, so that infected poultry does not develop any symptoms, mainly to cause human disease. The mutation of the virus will now make the infection in poultry evident, since the virus acquired a highly pathogenic trait. Second, there are cases of resistance to Tamiflu, recently found in Guangdong 2 cases with viremia and spread of the virus into the upper and lower respiratory tract, and resistance to Tamiflu.

"Now, there are a lot of unknown." First, there is no mean to know whether the drug-resistant strains will become later widespread and dominant.

‘’Second, whether these resistant strains are widely circulating is not presently known, so there is need for an increased surveillance.’’

Zhong Nanshan stressed that even if this would be the case, the public do not need to panic, and until now in many cases treated, Tamiflu showed to be effective, because the mutant Has not become a widespread, a considerable part of the virus had no variation.

Guangdong Provincial Center for Disease Control and Prevention of infectious diseases prevention and control of the chief expert He Jianfeng also said that these two cases is caused by drug resistance or virus mutation caused by the impact is not yet determined, but this is indeed a matter of concern.

If there is resistance to mutant virus strains, treatment options will be adjusted? Zhong Nanshan explained that mutant virus strains have just been found soon, the adjustment program is too early. There is also a combination of methods, and H7N9 virus treatment is the most critical or supportive therapy.

"From our experience, the avian flu virus on the patient's lung injury is the largest, severe patients will harden the entire lung, and finally respiratory failure, while the heart, kidneys have different degrees of harm.Therefore we in the anti-virus treatment At the same time, to support these important organs of the therapy, if these important organs can support live, you can survive the dangerous period.

"Not to say that after the mutation on the patient mortality rate is higher, and now also not the conclusion, the current case data is too small, is closely observed." Zhong Nanshan that even Guangdong has taken a very strong measure, but Guangdong Like the habit of eating chicken is difficult to change, so I hope the media appeal, the public do not contact live chickens, because most of the live chickens are backyard.

"Although there is no obvious phenomenon of people coming, but there is fever, soon to medication, because the effect of drug is the first 5 days more effective, behind the effect is not very good, we must increase the dose. At the same time, after scientific demonstration, in response to influenza, such as … and other proprietary Chinese medicines for improving physical resistance, reduce inflammation is indeed effective, the relevant research results will be announced.

H7N9 Avian flu into the high incidence of the national death toll has increased to 87 people

According to the latest statistics of the State Health Commission, February 6 to 12, the national report H7N9 cases 69 cases, 8 people died! January people infected with death 79 people! 19, Guangdong H7N9 infected cases found in the virus mutant strains.

Yangtze River Delta Pearl River Delta is the highest incidence of H7N9 epidemic in Jiangsu

The high incidence of the epidemic this year scattered in the Yangtze River Delta and the Pearl River Delta region. Up to now the public report, Jiangsu Province, the largest number of infections, up to 124 people, of which 35 were killed. The remaining provinces of Zhejiang, Guangdong, Anhui, Jiangxi, Fujian, Hunan, Hubei and other provinces have reported H7N9 avian influenza virus infection cases and deaths. According to Xinhua News Agency, China CDC virus disease deputy director, director of the National Center for Influenza Shu Yuelong said that since last winter, due to climate and other factors, the global animal avian flu epidemic was high trend, spread to Asia, Europe , The Middle East nearly 40 countries and regions. This year, China's H7N9 not only distributed in the region than ever before, the number of cases of infection and death are the largest number of four years, the current situation, the mortality rate of about 40%.

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Keywords: China; H7N9; Avian Influenza; Human; Antivirals; Drugs Resistance; Oseltamivir.

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#China Academy of Science’s Zhong Nanshan said the #H7N9 #flu #virus found in #Guangdong from two patients was #drugsresistant (RTHK, Feb. 26 ‘17)

 

Title: China Academy of Science’s Zhong Nanshan said the H7N9 influenza virus found in Guangdong from two patients was drugs resistant.

Subject: Avian Influenza, H7N9 subtype, human cases in China.

Source: RTHK, full page: (LINK). Article in Chinese, edited.

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Zhong Nanshan said that two H7N9 virus variants were found to be resistant to specific drugs

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2017-02-26 HKT 15:15

Chinese Academy of Science researcher Zhong Nanshan said that Guangdong recently found two H7N9 avian influenza virus with mutations making highly pathogenic for poultry, and resistant to some antiviral medications.

He said that the virus was found in the blood of both patients and in the upper and lower respiratory tract.

However, Zhong Nanshan said that at present most patients [improved] with special treatment [that seems to be] effective, indicating that the mutated virus is not widespread.

He called on the public, do not touch live birds, once the fever and other flu symptoms, to timely seek medical treatment.

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Keywords: China; Guangdong; H7N9; Avian Influenza; Human; Antivirals; Drugs Resistance; Oseltamivir.

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25 Feb 2017

#Influenza and other #Respiratory #Viruses #Research #References #Library–February 25 2017 Issue

 

Title: #Influenza and other #Respiratory #Viruses #Research #References #Library–February 25 2017 Issue.

Subject: Human and Animal Influenza Viruses, other respiratory pathogens research, weekly references library update.

Source: AMEDEO, homepage: (LINK).

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This Week’s References:

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  1. HAWKES N.
  2. WISE J.
  3. GUDJONSSON A, Lysen A, Balan S, Sundvold-Gjerstad V, et al.
    • Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses.
  4. CHEUNG K, Ho SM, Lam W.
    • Factors affecting the willingness of nursing students to receive annual seasonal influenza vaccination: A large-scale cross-sectional study.
  5. CHEN LJ, Lin XD, Tian JH, Liao Y, et al.
    • Diversity, evolution and population dynamics of avian influenza viruses circulating in the live poultry markets in China.
  6. CHAIMAYO C, Hayashi T, Underwood A, Hodges E, et al.

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Keywords: Research; Abstracts; Influenza References Library.

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#Cholera, monthly report for #Yemen (@WHO EMRO, Feb. 25 ‘17)

 

Title: #Cholera, monthly report for #Yemen.

Subject: Cholera Outbreak in Yemen, current epidemiological situation.

Source: World Health Organization (WHO), Office for the Eastern Mediterranean Region, full page: (LINK).

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Cholera monthly report for Yemen

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|-- Read the latest update for cholera in Yemen –|

Summary

  • A total of 3130 new suspected cholera cases and 0 deaths were reported in Yemen for January 2017.
  • The cumulative number of suspected cases of cholera reported since the start of the outbreak in October 2016 is 18 973 cases, including 99 deaths with a case-fatality rate of 0.5%. More than one third of the cases were children under the age of 5.
  • Of the new cases reported, 11 stool samples were laboratory-confirmed for Vibrio Cholerae 01.
  • The trend of suspected cholera cases has been declining over the past few weeks as prevention measures take hold across the country.
  • In 2016, the cumulative number of suspected cholera cases was 15 843, including 531 associated deaths, with a case-fatality rate of 0.6%.

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Keywords: WHO; Updates; Cholera; Yemen.

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#China, #Jiangsu: a new #human case of #H7N9 #influenza reported in Zaozhuang (Feb. 25 ‘17)

 

Title: China, Jiangsu: a new human case of H7N9 influenza reported in Zaozhuang.

Subject: Avian Influenza, H7N9 subtype, human case in Jiangsu province of China.

Source: Local Media, full page: (LINK). Article in Chinese, edited.

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A new case of human infection with H7N9 flu virus was found in Zaozhuang

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2017-02-25 11:35:35

February 22, Zaozhuang Tengzhou found a new person infected with H7N9 flu, currently being actively treated, the prevention and control work has been carried out.

Experts believe that the current H7N9 virus transmission route is still from the birds to people, exposure to infected poultry or exposed to live poultry market is an important risk factor for human infection.Experts recommend that the public should avoid contact with dead birds in daily life, try to avoid direct contact with live birds; should be purchased with quarantine certificate of fresh, live, frozen poultry and related poultry products; pay attention to food hygiene, food processing to be done Cooked to improve; self-protection awareness, found that there are fever and respiratory symptoms, should wear a mask, as soon as possible treatment.

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Keywords: China; Jiangsu; H7N9; Avian Influenza; Human.

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#China, #Henan province reported three #human cases of #H7N9 #influenza in the last nine days (Feb. 25 ‘17)

 

Title: China, Henan province reported three human cases of H7N9 influenza in the last nine days.

Subject: Avian Influenza, H7N9 subtype, human cases in Henan province of China.

Source: Local Media, full page: (LINK). Article in Chinese, edited.

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Henan Province, 3 cases of human infection H7N9 influenza reported from Feb. 16 to Feb. 24

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2017-02-25 11:04:44

Zhongyuan network news (reporter Xing Zheng reported financial media into the valley Changle) 16 to 24 February, the province added two H7N9 human cases (in Shangqiu), one case in Nanyang City, a total of three cases of human infection with H7N9 influenza. Among them, 1 case is in serious condition, currently hospitalized.

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Keywords: China; Henan; H7N9; Avian Influenza; Human.

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#China, #Guizhou province reported a #human case of #H7N9 #influenza #infection (Xinhua, Feb. 25 ‘17)

 

Title: China, Guizhou province reported a human case of H7N9 influenza infection.

Subject: Avian Influenza, H7N9 subtype, human case in Guizhou province of China.

Source: Xinhua, full page: (LINK). Article in Chinese, edited.

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A case of human infection with H7N9 flu virus reported in Leishan County, Guizhou Province

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2017-02-25 14:13:15 Source: Xinhua News Agency

Xinhua News Agency, Guiyang, February 25 (Reporter Li Jing Ya) reporter learned from the Guizhou Provincial Satellite TV Commission, Guizhou Province, Guizhou Southeast Miao and Dong Autonomous Prefecture, Leishan County, a recent case of human infection with H7N9 flu, the patient is currently active treatment.

It is understood that Qiandongnan Medical and Health Unit recently in the strengthening of pneumonia monitoring, from Lei Shan County detected 1 case of unexplained pneumonia, then confirmed being H7N9 influenza virus positive, by the Guizhou Provincial CDC laboratory review and clinical expert diagnosis of human infection H7N9 Influenza cases.

The patient is a 51 years old, now living in Southeast Guizhou Leishan County. After investigation, the case before the onset of contact with live birds. At present, all patient’s close contacts are under medical observation, and so far none showed symptoms.

After the outbreak, the provincial, state and county health care departments immediately organized medical institutions to treat patients, the relevant departments to actively carry out epidemic prevention and control and market monitoring and management work.

It is reported that Qiandongnan this year so far reported 3 cases of human infection with H7N9 virus; of these, a case recovered and discharged, whereas the other two are currently under treatment.

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Keywords: China; Guizhou; H7N9; Avian Influenza; Human.

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#China, #Guangxi reported a #fatal #human #infection with #H7N9 #influenza (Feb. 25 ‘17)

 

Title: China, Guangxi reported a fatal human infection with H7N9 influenza.

Subject: Avian Influenza, H7N9 subtype, human case in Guangxi province of China.

Source: Local Media, full page: (LINK). Article in Chinese, edited.

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Guangxi added a case of human infection with H7N9 flu

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2017-02-25 14:54:44

Nanning, February 25 (Xinhua Huang Yanmei) Guangxi Zhuang Autonomous Region Health and Family Planning Commission on the 25th reported a case of human infection with H7N9 flu; the patient died after hospitalization.

This year, Guangxi reported three fatal cases of human infection with H7N9 virus.

According to the briefing, the patient was in Guilin, Guangxi Pingle County, before the symptoms onset he ate their own chicken; he was in critical condition, then passed away.

(…)

A few days ago, Nanning City, Guangxi reported that one case of H7N9 human infection, a farmers in the market for live poultry sales, died on the 19th of this month.

(…)

At present, 14 municipal CDC in Guangxi have the H7N9 virus laboratory testing capabilities. (Finish)

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Keywords: China; Guangxi; H7N9; Avian Influenza; Human.

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#China, #Jiangxi province reported two #human cases of #H7N9 #influenza in the last ten days; 30 so far this year (Feb. 25 ‘17)

 

Title: China, Jiangxi province reported two human cases of H7N9 influenza in the last ten days; 30 so far this year.

Subject: Avian Influenza, H7N9 subtype, human cases in Jiangxi province of China.

Source: Ifeng, full page: (LINK). Article in Chinese, edited.

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Jiangxi reported two new human cases of H7N9 influenza, epidemic stabilized

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2017 / February 25 13:24:20

February 24, Jiangxi Provincial Health Commission issued the latest H7N9 epidemic report: from 2017 January 1 to February 23, the province reported 30 cases of H7N9 influenza with 10 deaths.

Between February 13 and Feb. 23, Jiangxi Province, reported two new human cases. At present, Jiangxi Province H7N9 epidemic tends to be stable.

Reporters learned that the current H7N9 epidemic remains widespread, H7N9 virus transmission is still from the birds to people, exposure to infected birds or exposed to live poultry market is an important risk factor for human infection.

It is reported that the most recent period, H7N9 sporadic cases may continue to appear. Experts recommend that the public should avoid contact with dead birds in daily life, try to avoid direct contact with live birds; should be purchased with quarantine certificate of fresh, live, frozen poultry and related poultry products; pay attention to food hygiene, food processing to be done Cooked to improve; self-protection awareness, found that there are fever and respiratory symptoms, should wear a mask, as soon as possible treatment.

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Keywords: China; Jiangxi; H7N9; Avian Influenza; Human.

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#HK CHP notified of 28 #human cases of #influenza #H7N9 in #China [Feb. 13-23 ‘17] (Feb. 25 ‘17)

 

Title: #HK CHP notified of 28 #human cases of #influenza #H7N9 in #China [Feb. 13-23 ‘17].

Subject: Avian Influenza, H7N9 subtype, human cases reported in China

Source: Centre for Health Protection, Hong Kong PRC SAR, full page: (LINK).

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CHP notified of human cases of avian influenza A(H7N9) in Mainland

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The Centre for Health Protection (CHP) of the Department of Health today (February 25) received notification from the National Health and Family Planning Commission that 28 additional human cases of avian influenza A(H7N9), including four deaths, were recorded from February 13 to 23. The CHP strongly urges the public to maintain strict personal, food and environmental hygiene both locally and during travel.

The 22 male and six female patients aged from four to 81 had their onset from January 27 to February 17.

The cases were from:

  1. Anhui (five cases),
  2. Guangdong (five cases),
  3. Jiangsu (four cases),
  4. Zhejiang (four cases),
  5. Henan (three cases),
  6. Hunan (two cases),
  7. Jiangxi (two cases), and
  8. one case each in Fujian, Hubei and Shandong.

Among them, 17 reported exposure to poultry or poultry markets.

In addition, the CHP is closely monitoring one additional human H7N9 case reported in Guangxi. According to the Health and Family Planning Commission of Guangxi Zhuang Autonomous Region, a patient in Pingle County with exposure to poultry has died.

(…)

The public may visit the CHP's pages for more information:

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Ends/Saturday, February 25, 2017 / Issued at HKT 12:56 / NNNN

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Keywords: HK PRC SAR; Updates; China; Avian Influenza; H7N9; Human.

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